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  M. G. Beaver,* E. Zhang, * Z. LiuS. ZhengB. WangJ. LuJ. TaoM. Gonzalez, S. Jones, J. S. Tedrow, Development and Execution of a Production-Scale Continuous [2+2] Photocycloaddition, Org. Process Res. Dev. 2020, ASAP.

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P. Garcia-Losada,* A. C. DeBaillie, J. E. Diego, S. J. Green, M. M. Hansen, C. Jaramillo, M. Johnson, T. Kaoudi, J. Li, P. J. Lindsay-Scott, C. Mateos, D.J. Mergott, J. A. Rincon, R.R. Rothhaar, K. D. Seibert, B. M. Watson, L. L. Winneroski, S. GangulaD. JingH. SunL. Zhang, and M. O. Frederick,* Synthesis, Optimization, and Large-Scale Preparation of the LowDose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3 + 2] Nitrone Cycloaddition, Org. Process Res. Dev. 202024, 306−314.

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Borovika, Alina; Albrecht, Jacob; Li, Jun; Wells, Andrew S.; Briddell, Christiana; Dillon, Barry R.; Diorazio, Louis J.; Gage, James R.; Gallou, Fabrice; Koenig, Stefan G.; et al. The PMI Predictor app to enable green-by-design chemical synthesis. Nat Sustain 2, 1034–1040 (2019).


V. S. Chan, S. W. Krabbe,C. LiL. SunY. Liu, A. J. Nett, Identification of an Oxalamide Ligand for Copper-Catalyzed C–O Couplings from a Pharmaceutical Compound Library,ChemCatChem 2019, 11, 5748-5753. .


  Y. Takahira, M. Chen, Y. Kawamata, P. Mykhailiuk, H. Nakamura, B. K. Peters, S. H. Reisberg, C. Li, L. Chen, T. Hoshikawa, T. Shibuguchi, P. S. Baran, Electrochemical C(sp3)–H Fluorination, Synlett, 201930,1178-1182.


 Y. Kawamata, J. C. Vantourout, D. P. Hickey, P. Bai,L. ChenQ. HouW. Qiao, K. Barman, M. A. Edwards, A. F. G.-C., J. N. deGruyter, H. Nakamura, K.W. Knouse, C. Qin, K. J. Clay, D. Bao, C. Li, J. T. Starr, C. G. Irizarry, N. Sach, H. S. White, M. Neurock, S. D. M., P. S. Baran, Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications, J. Am. Chem. Soc.2019141,6392-6402.


  B. K. Peters, K. X. Rodriguez, S. H. Reisberg, S. B. Beil, D. P. Hickey, Y. Kawamata, M. Collins, J. Starr, L. Chen, S. Udyavara, K. Klunder, T. J. Gorey, S. L. Anderson, M. Neurock, S. D. Minteer, P. S. Baran, Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry, Science2019, 363, 838-845.



 J. Wang, H. Lundberga, S. Asaia, P. Martín-Acostaa, J. S. Chena, S. Brownb, W. Farrellc, R.G. Dushin, C. J. O’Donnell, A. S. Ratnayakeb, P.  Richardsonc, Z. Liu, T. Qin, D. G. Blackmond, P. S. Barana, Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA,Proc. Natl. Acad. Sci.2018115, E6404-E6410.锚点锚点


R.R. Merchant, J. T. Edwards, T. Qin, M. M. Kruszyk, C. Bi,G. Che, D. Bao, W. Qiao L. Sun, M. R. Collins, O. O. Fadeyi, G. M. Gallego, J. J. Mousseau, P. Nuhant, P. S. Baran, Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds,Science2018360,75-80.


This is one of more than 60 examples of radical cross-couplings using new sulfone reagents with unique reactivity.

D. E. Hill, Q. PeiE. ZhangJ. R. Gage, J. Yu, D. G. Blackmond, A General Protocol for Addressing Speciation of the Active Catalyst Applied to Ligand-Accelerated Enantioselective C(sp3)−H Bond Arylation, ACS Catal. 20188, 1528−1531.



J.N. deGruyter, L. R. Malins, L. Wimmer, K. J. Clay, J. Lopez-Ogalla, T. Qin, J. Cornella, Z. LiuG. CheD. Bao, J. M. Stevens, J. X. Qiao, M. P. Allen, M. A. Poss, P. S. Baran, CITU: A Peptide and Decarboxylative Coupling Reagent, Org. Lett. 201719, 6196-6199.



 Q. Pei, G. Che, R. Zhu, J.He, J. Yu,  An Epoxide-Mediated Deprotection Method for Acidic Amide Auxiliary, Org. Lett. 2017, 19, 5860-5863.


 C. Li, Y. Kawamata, H. Nakamura, J. C. Vantourout, Z. Liu, Q. Hou, D. Bao, J.T. Starr, J.Chen, M. Yan, P.S. Baran, Electrochemically Enabled, Ni-Catalyzed Amination, Angew. Chem. Int. Ed., 2017, 56, 13088-13093.


 J. M. Smith, T. Qin, R. R. Merchant, J. T. Edwards, L. R. Malins, Z. Liu, G. Che, Z. Shen, S. A. Shaw, M. D. Eastgate, P. S. Baran*, Decarboxylative Alkynylation, Angew. Chem. Int. Ed., 2017, 56, 11906-11910.


  E. Hansen*, C. LiS. Yang, D. Pedro, D. Weix*, Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling, J. Org, Chem.201782, 7085-7694.


Y. Kawamata, M. Yan, Z. Liu,D. Bao, J. Chen, J. T. Starr, P. S. Baran*, Scalable, Electrochemical Oxidation of Unactivated C−H Bonds,J. Am. Chem. Soc.,2017, 139, 7448–7451.


 J. T. Edwards, R. R. Merchant, K. S. McClymont, K. W. Knouse, T. Qin, L. R. Malins, B. Vokits, S. A. Shaw, D.Bao, F. Wei, T. Zhou, M. D. Eastgate, P. S. Baran*, Decarboxylative alkenylation, Nature, 2017, 545,213-218.



 E. Zhang*, J. Tang, S. Li, P. Wu, J. E. Moses, K. B. Sharpless*,Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates, Chem. Eur. J.201622, 5692 – 5697.


E. J. Horn, B. R. Rose, Y. ChenJ. Tang, K. Chen, M. D. Eastgate, P. S. Baran*,  Scalable and sustainable electrochemical allylic C-H oxidation, Nature,2016533, 78-81.锚点锚点



 J. R. Gage,*X. Guo, J.Tao, C. Zheng, High Output Continuous Nitration, Org. Process Res. Dev. 2012, 16, 930−933.


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